1q1c

Crystal structure of N(1-260) of human FKBP52


The 3D structures of several FKBP family members from various species are solved, most of them comprise 1-2 FK domains (e.g. human FKBP52), while wFKBP73 (e.g. 3jym) has 3 FK domains which is characteristic to plants. A sequence-based structure comparison between each of the 3 FK domains of wFKBP73 (3jym) and the 2 FK domains of hFKBP52 (1q1c) was performed. All 3 FK domains of wFKBP73 adopt a typical FK fold exhibiting significant diversity when superimposed. They are arranged in a linear manner in space as observed in the 2 FK domains of hFKBP52. While the 2 FK domains of hFKBP52 are in the same orientation, the orientation between any 2 consecutive wFK73 domains is different than that between the two FK domains of hFKBP52. Superposition of the wFK73_1 (in blueviolet) and wFK73_2 (in cyan) domains (3jym) on hFK52_1 (in yellow) and hFK52_2 (in blue) revealed that while wFK73_2 is perfectly aligned with hFK52_2, N-terminal wFK73_1 does not align with hFK52_1 (yellow). Similarly, superposition of the wFK73_2 and wFK73_3 (in magenta) domains on hFKBP52 revealed that while wFK73_2 is perfectly aligned with hFK52_1 (in yellow), wFK73_3 does not align with hFK52_2. This unique arrangement of wFKBP73 causes that the α-helices of wFKBP73 3 FK domains are exposed on the same surface, while the 2 α-helices of hFK52 are presented on opposite surfaces.

About this Structure
1Q1C is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference
Page seeded by OCA on Wed Feb 18 03:42:17 2009